For my part, I never buy for collecting what I am not expecting to enjoy if opened. So far, very few disappointments.
If you are not going to sell them (or give them away to the very welcoming and thankful hands of forum members) and you get tired of looking at them for their aesthetic value, then opening them is your only other choice. When opening them, pick the bottle according to a special occasion whether that be an event or with a special friend. I find that how the bottle was shared creates a great memory that persists long after the whisky is gone.
Now, after saying that, however, I do have some reluctance in finishing a bottle that I will probably never taste again. Reluctance always, in the end, gives way to enjoyment.
Truly, just do what you want with the bottles, whatever that is.